Using insulated tubing as production string is an effective measure to raise wellhead oil temperature and to reduce energy consumption of gathering and transportation system. Through investigation and analysis, optimization of aerogel as heat insulation material for insulated tubing, the thermal insulation effect of the insulated tubing is further verified by the measured data. Taking the actual oil well as an example, the governing equations of flow and heat transfer for down hole insulated tubing are established, the heat transfer characteristics of the insulated tubing are numerically simulated, and the influence of different insulation structures on the temperature drop of the oil flow in the pipe is studied. The results show that the four insulation structures meet the production requirements by using 6 mm,10 mm,6 mm+10 mm and 3 mm+10 mm, which provides a theoretical basis for the production of thermal insulation tubing by aerogel nano insulation materials.